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To accurately measure the beggingof the breath, it should correspond to the timepoint when the initial ?ow crosses the zero linefor ?ow signaling patient triggering or openingof the inspiratory valve in controlled breaths.Unfortunately, these two time points can cor-respond to times of high turbulence thus highsignal noise. PRIMA-1is the molecule that has progressed farther in clinical trials, and hydrolytic productsof PRIMA-1 might covalently react to cysteine residues in the mutated DBD toactivate p53 [ 36].
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